Technology always plays a key role in the great challenges that are currently facing humanity. Talking about digital, energy, mobility, climate, health or humanity in general, technology is mostly at the core. However, nowadays challenges cannot be reduced to a mere technical data, either analysing or designing possible solutions. To comprehend and face them successfully, all forms of knowledge are essential, from the techno-scientific field to the human, social and artistic ones. The “Big Challenges” courses are an opportunity to examine with interdisciplinary lens a number of relevant topics concerning humanity, focusing on technology and its key role on human living. In this framework, all the courses will address the UN Sustainable Development Goals, a global initiative aimed at renewing local and international policy. In particular, the present course aims at presenting some basic concepts related to cybersecurity: after a general introduction to the concept of security, it introduces the most relevant sources of vulnerabilities, targeting three different domains (organizational, technical, and human) and analyses some of the most widely adopted solution to overcome them. The course then focuses on the most relevant frameworks of laws, regulations, and standards established at National, European, and International level. From an operative point of view, attendees will then be invited to set up groups of 4-5 people and each group will have to carry on a research project work, whose topic will be freely selectable from a portfolio of proposed ones. Attendees will be asked to fill an assessment test (i.e. survey) both at the beginning and at the completion of the course. The questionnaire is guaranteed to be fully anonymous and is prepared by the CINI Cybersecurity National Laboratory (https://cybersecnatlab.it) within the project CyberReadiness.IT.