University College Cork

Molecular Basis of Brain Disorders

BC4011

Iowa State Course Substitution

CH E Professional Elective

CH E

Course Info
International Credits:
5.0
Converted Credits:
3.0
Semester:
spring
Country:
Ireland
Language:
English
Course Description:
The history and current understanding of the molecular pathogenesis of Alzheimer's disease. Focus on the structure, function and role of the key pathogenic proteins in Alzheimers disease: the amyloid precursor protein, tau, presenilin complex and Apolipoprotein E. Development of transgenic animal models of Alzheimer's disease. The amyloid hypothesis and other theories towards understanding the molecular pathogenesis of Alzheimer's disease. The history and current understanding of the molecular pathogenesis of Parkinson's disease. Focus on the structure and function of the key pathogenic proteins in Parkinson's disease: alpha synuclein and the PARK genes. Development of models and treatment strategies for Parkinson's disease. Current hypothesis of neurodegeneration in Parkinson's disease, with focus on mitochondrial dysfunction, oxidative stress and the ubiquitin proteasomal system. The history and current understanding of the molecular pathogenesis of Huntington's disease. Mechanisms of neurodegeneration brought about by mutant huntington, models and treatment. Methods used to understand molecular basis of neurodegeneration.

Review

Evaluation Date:
November 30, 2016
Evaluated:
Monica Lamm
Comments:
Professional elective