University Of Limerick

Orthopaedic Biomechanics and Mechanobiology

ME 4008

Iowa State Course Substitution

ME Technical Elective


Course Info
International Credits:
Converted Credits:
Course Description:
Module Code - Title: ME4008 - ORTHOPAEDIC BIOMECHANICS AND MECHANOBIOLOGY Year Last Offered: 2017/8 Hours Per Week Grading Type: Prerequisite Modules: Rationale and Purpose of the Module: This module will provide the student with an understanding of the role of mechanics in regulating orthopaedic tissue development and homeostasis at both the organ and cellular level. Syllabus: Development and structure of bone; Bone biomechanics; Composition and structure of cartilage; Cartilage biomechanics; Structure and mechanics of the ligament and tendon; Computational models in orthopaedic biomechanics; Cell mechanics; Models of cell mechanical behaviour; Cellular mechanotransduction; Bone mechanobiology; Cartilage mechanobiology; Ligament and tendon mechanobiology; Techniques in mechanobiology; Mechanical stimulation of cells; Orthopaedic tissue engineering; Bioreactors in Tissue Engineering; Learning Outcomes: Cognitive (Knowledge, Understanding, Application, Analysis, Evaluation, Synthesis) On successful completion of this module the student will be able to, 1. Describe the composition, structure and mechanical function of bone, cartilage, ligament and tendon within the human body. 2. Characterise the mechanical behaviour of these tissues using the principles of engineering mechanics. 3. Describe the structure of a eukaryotic cell and characterise its mechanical behaviour using mathematical models. 4. Derive the equations necessary to determine the mechanical properties of a cell from data collected using techniques such as atomic force microscopy Lecture Lab Tutorial Other Private Credits 2 2 1 0 0 6 5. Describe the principles of orthopaedic tissue engineering. 6. Give an overview of the role of mechanics in orthopaedic tissue formation. 7. Using the mechanical laws governing tissue formation, demonstrate how they can be incorporated into computational models to predict orthopaedic tissue repair in clinical conditions such as bone fracture and tissue engineering environments. 8. Write a technical report on their experimental findings using correct formatting. Affective (Attitudes and Values) N/A Psychomotor (Physical Skills) On successful completion of this module the student will be able to, 1. Mechanically test bone and cartilage to determine their mechanical properties. 2. Use brightfield and fluorescent microscopes to visualise orthopaedic tissue at the macro and cellular level. How the Module will be Taught and what will be the Learning Experiences of the Students: Lectures, Laboratory work and tutorials Research Findings Incorporated in to the Syllabus (If Relevant): Linked to on-going research in CABER Prime Texts: Jacobs C.R., Kwon R Huang H. (2012) An Introduction to Cell Mechanics and Mechanobiology, Taylor and Francis. Mow V.C & Huiskes R. (2005) Orthopaedic Biomechanics and Mechanobiology (Third Edition), Williams and Wilkins. Ethier R.C. & Simmons C.A. (2008) Introductory Biomechanics, Cambridge. Other Texts: Gefen A. (2011) Cellular and Biomolecular Mechanics and Mechanobiology, Springer. Currey J.D. (2006) Bones: Structure and Mechanics, Princeton University Press Lee C.R. & Niederer P. (2009) Basic Engineering for Medics and Biologists, IOS Press. Van Blitterswijk C. (2008) Tissue Engineering, Academic Press. Programmes Semester - Year to be First Offered: Module Leader:


Evaluation Date:
November 1, 2017